About familial eosinophilic cellulitis

What is familial eosinophilic cellulitis?

Familial eosinophilic cellulitis is a rare skin disorder. It is characterized by raised, red, swollen, and warm areas of skin, in a flame-shaped pattern with associated pain. The exact cause of the disease is unknown. However, bites of spiders, bees, mites, fleas, or ticks (arthropods) are often associated with this skin condition.



What are the symptoms for familial eosinophilic cellulitis?

Familial eosinophilic cellulitis is a rare skin disorder. It sometimes occurs as an exaggerated response to bites of spiders, bees, fleas, ticks, or mites (arthropods), or it may have other causes such as surgery or drugs. The skin of the person will develop flame shaped patterns of raised, swollen, red areas that are warm to the touch. The episodes usually come on rapidly. Often, familial eosinophilic cellulitis will recur suddenly over a period of years with Swelling and Redness developing for no apparent reason. The attack may last up to six weeks and may continue to recur for years.

Large areas of skin may be affected and testing shows microscopic changes of the tissue. An abnormal number of white blood cells (eosinophils) are found in the red and swollen areas of skin, underlying fat, and usually in the blood. Skin Blistering has also been known to develop.



What are the causes for familial eosinophilic cellulitis?

The exact cause of familial eosinophilic cellulitis is still not known. Some scientists believe that there may be an autoimmune basis for the disorder. Autoimmune disorders are caused when the body’s natural defenses (antibodies, lymphocytes, etc.), against invading organisms suddenly begin to attack perfectly healthy tissue.



What are the treatments for familial eosinophilic cellulitis?

Standard treatment of familial eosinophilic cellulitis may consist of administration of steroid drugs. However, the disorder often resolves itself after a number of weeks. Other treatment is symptomatic and supportive.



What are the risk factors for familial eosinophilic cellulitis?

Skin peeling syndrome or familial continuous skin peeling happens on its own, is painless, and can last a lifetime while gradually getting better. Like skin peeling after a severe sunburn, affected people and/or their caretakers might frequently manually remove sheets of skin.

  • Applying skin-softening (emollient) ointments to treat peeling skin syndrome, particularly after a bath when the skin is moist, may provide some relief.
  • Vaseline or plain petroleum jelly are recommended.
  • None of the corticosteroids or systemic retinoids (derivatives of vitamin A) are recommended or effective, and all have the potential to have negative consequences.
  • Genetic counseling is advised for affected individuals and their families to explore the possibilities of genetic testing as well as the risk of having children with this condition.


Symptoms
Abnormal blistering of the skin,Abnormality of hair texture,Dry Skin,Aminoaciduria,Hyperhidrosis,Ichythosis
Conditions
Skin fragility,Lifelong peeling of the stratum corneum,Pruritus,Short stature,Easily removed anagen hair
Drugs
Ibuprofen,Naproxen



Is there a cure/medications for familial eosinophilic cellulitis?

Familial eosinophilic cellulitis is a skin disorder. It is distinguished by painful, elevated, red, swollen, and warm patches of skin that have a flame-like appearance. The exact causes are yet to be discovered. However, this skin condition is frequently linked to arthropod attacks from spiders, bees, mites, fleas, or ticks.

  • The standard treatment for familial eosinophilic cellulitis may include steroid medication., including topical and systemic corticosteroids, antihistamines, cyclosporine, dapsone, azathioprine, griseofulvin, doxycycline, minocycline, antimalarials, oral tacrolimus/topical tacrolimus, sulfasalazine, interferon alpha and gamma, TNF alpha inhibitors No recommendations for the therapy of this disease can be made since well-designed, randomized controlled trials are not available.
  • Systemic therapy should only be used in situations that are resistant to local therapy or have broad lesions because of the favorable prognosis and propensity to resolve.


Symptoms
Swollen, red, raised, and warm areas of skin,
Flame-shaped pattern with pain,Flame shaped patterns of raised, swollen, red areas that are warm to the touch,Painful, red, raised, warm patches of skin
Conditions
Irritated and itchy skin,Cellulitis,Contact dermatitis,Severe allergic reactions such as anaphylaxis
Drugs
Corticosteroids,Topical corticosteroids,Antihistamines



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