Many people who become infected with non-polio enteroviruses either have no symptoms from the infection or experience only a mild illness. When symptoms do occur, they often resemble those of the common cold: fever, malaise, cough, and runny nose. More serious infections can cause wheezing, shortness of breath or difficulty breathing, rapid heart rate, reddened skin, or cyanosis (a bluish tinge to the skin).
In rare cases, the enterovirus infection spreads to the central nervous system, leading to headache, stiff neck, and sensitivity to light and in severe cases, lethargy, seizures, personality changes, paralysis, and coma.
Other possible non-polio enteroviruses symptoms include body aches, eye pain, chest pain, fever, rash, skin blisters, nausea, vomiting, and irritability.