Swelling of the lips can arise due to different conditions. Trauma to the lip and mouth area is an obvious cause of swollen lips. Allergic reactions, either to foods or other substances, can often be accompanied by swelling of the lips. Angioedema is a condition in which there is swelling of the tissue beneath the skin, and this is often concentrated around the eyes and lips. Some infections (such as herpes simplex virus infection) can result in blisters and localized swelling of the lips. Infections and inflammatory conditions of the skin can also lead to inflammation and swollen lips (cheilitis). Less commonly, medical conditions that affect the entire body may cause lip swelling, sometimes in association with fluid retention or swelling in other areas of the body.