Disease: Sun-Sensitive Drugs
(Photosensitivity to Drugs)

    Sun-sensitizing drugs (photosensitivity) facts

    • Many common medications may cause a reaction in some individuals that is similar to sunburn.
    • Symptoms of sun sensitivity are similar to those of sunburn.
    • The phototoxic reactions may happen within hours of exposure to sun.
    • The photoallergic reactions may happen after several days of exposure to sun.

    What is photosensitivity?

    Photosensitivity (or sun sensitivity) is inflammation of the skin induced by the combination of sunlight and certain medications or substances. This causes redness (erythema) of the skin and may look similar to sunburn. Both the photosensitizing medication or chemical and light source have to be present in order for a photosensitivity reaction to occur.

    Generally, these reactions can be divided into two mechanisms, 1) phototoxic reactions and 2) photoallergic reactions. Phototoxic drugs are much more common than photoallergic drugs.

    What is the difference between a photoallergic and a phototoxic reaction?

    Phototoxic reactions

    In phototoxic reactions, the drug may become activated by exposure to sunlight and cause damage to the skin. The skin's appearance resembles sunburn, and the process is generally acute (has a fast onset). Ultraviolet A (UVA) radiation is most commonly associated with phototoxicity, but ultraviolet B (UVB) and visible light may also contribute to this reaction.

    Rash from a phototoxic reaction is mainly confined to the sun-exposed area of the skin. A phototoxic reaction typically clears up once the drug is discontinued and has been cleared from the body, even after re-exposure to light.

    Photoallergic reactions

    In photoallergic reactions, the ultraviolet exposure changes the structure of the drug so that is seen by the body's immune system as an invader (antigen). The immune system initiates an allergic response and cause inflammation of the skin in the sun-exposed areas. These usually resemble eczema and are generally chronic (long-lasting). Many drugs in this family are topical drugs.

    This type of photosensitivity may recur after sun exposure even after the drug has cleared from the system and can sometimes spread to areas of the skin unexposed to the sun.

    What is ultraviolet light?

    Ultraviolet (UV) light is radiation energy in the form of invisible light waves. UV light is emitted by the sun and by tanning lamps.

    The sun discharges three types of ultraviolet radiation:

    1. ultraviolet A (UVA)
    2. ultraviolet B (UVB)
    3. ultraviolet C (UVC)

    Only UVA and UVB rays reach earth. (UVC does not penetrate the earth's upper atmosphere.)

    Tanning lamps also produce UVA and/or UVB. These artificial rays affect the skin in the same way as do UVA and UVB from the sun.

    Photoallergic and phototoxic reaction pictures

    Picture of a photoallergic reaction Picture of photoallergic and phototoxic dermatides Picture of a phototoxic drug reaction Picture of a phototoxic drug induced photosensitivity

    Photoallergic drugs

    Some of the common topical photoallergic drugs are the following:

    Sunscreens
    • para-aminobenzoic acid (PABA) - PABA has been phased out of sunscreen preparations because of the high rate of allergic reactions to this chemical.
    • oxybenzone
    • cyclohexanol
    • benzophenones
    • salicylates
    • cinnamate
    Anti-microbials
    • chlorhexidine (Peridex)
    • hexachlorophene (Phisohex, Septisol)
    • dapsone (DDS)

    Learn more about: Cipro | Cipro XR | Proquin XR | Levaquin | Vibramycin | Oracea | Adoxa | Atridox | Bactrim | Septra | Gantanol

    Painkillers
    • celecoxib (Celebrex)

    Learn more about: Benadryl

    Cancer chemotherapy drugs
    • 5-fluorouracil (5-FU, Efudex, Carac, Fluoroplex)
    Fragrances
    • Musk
    • 6-methylcoumarine

    These are only some of the common sun-sensitizing drugs.

    Are there any medical conditions that may cause photosensitivity?

    Some medical conditions are known to cause sensitivity to sun exposure.

    Systemic lupus erythematosus (SLE) often causes a rash on the face which can be very sensitive to sunlight. This rash is typically seen on the nose and cheeks, called a malar rash, and is considered one of the hallmarks of lupus.

    Porphyria is another medical condition that may cause photosensitivity reactions. This is a hereditary condition with skin manifestation (cutaneous porphyria) causing rashes and blisters in reaction to exposure to sunlight.

    Vitiligo is a relatively common disorder that causes patches of white de-pigmented skin. These patches lack melanin and are extremely sensitive to UV rays.

    Xeroderma pigmentosum is a disorder that appears to result from an inherited hypersensitivity to the cancer-causing (carcinogenic) effects of ultraviolet light. Sunlight causes DNA damage that is normally repaired. Individuals with xeroderma pigmentosum have defective inability to repair the DNA after UV damage. Affected individuals are hundreds of times more vulnerable to developing skin cancer than other people. Their extreme skin photosensitivity predisposes them to pronounced skin damage and scarring and also to the early onset of skin cancer (basal cell and squamous cell carcinomas and malignant melanoma).

    Individuals with classic oculocutaneous albinism lack melanin in their skin and eyes -- hence, the term "oculocutaneous" ("oculo" for eyes, and "cutaneous" for skin). Without the protection of this pigment, their white skin and pink eyes are both highly sensitive to UV and susceptible to the rays' damage.

    How is sun sensitivity (photosensitivity) diagnosed?

    The diagnosis is mainly made by a thorough history, examination, and review of the medications and duration of exposure to sun. It is important to ask when the medication was started and for how long the symptoms persisted.

    There are no diagnostic tests available, although a photo-patch test may be performed. This test is typically performed by a dermatologist (a doctor who specializes in diseases of the skin) by shining light onto different areas of the skin to see how long it will take for the light to cause redness. This test may be useful in evaluating photosensitivity to topical medications causing a photoallergic response. In cases of phototoxicity reactions, this test is generally not useful.

    What is the treatment for a photosensitizing drug reaction?

    Recognizing and discontinuing the photosensitizing drug is the most important step in treatment. In general, the usual sunburn prevention methods such as the use of sunscreens and avoidance of prolonged exposure to sun are important steps to take. Keeping the area of skin eruption moist and applying wet dressings may help relieve the symptoms. The reaction may last up to a few weeks.

    Topical steroid creams may be helpful in treating the redness, and antihistamines are generally helpful in minimizing the itching. In severe cases, a short course (10-14 days) of oral steroids, under the direction of a doctor, can be used.

    Is anyone taking these drugs at risk for developing sunburn?

    Not everyone taking any of these drugs will develop photosensitivity reactions. Certain individuals have more susceptibility to these medications than others.

    Can any foods or plants cause sun sensitivity (photosensitivity) reactions?

    Some vegetables and plants may cause sun sensitivity if they come into contact with the skin. Mango peel, lime juice, parsnips, or celery, for example, may cause temporary discoloration (darkening) of the skin contact area when in the sun. Common phototoxic fruits and vegetables include:

    • Lime
    • Celery
    • Carrots
    • Figs
    • Parsley
    • Parsnips

    What is ultraviolet light?

    Ultraviolet (UV) light is radiation energy in the form of invisible light waves. UV light is emitted by the sun and by tanning lamps.

    The sun discharges three types of ultraviolet radiation:

    1. ultraviolet A (UVA)
    2. ultraviolet B (UVB)
    3. ultraviolet C (UVC)

    Only UVA and UVB rays reach earth. (UVC does not penetrate the earth's upper atmosphere.)

    Tanning lamps also produce UVA and/or UVB. These artificial rays affect the skin in the same way as do UVA and UVB from the sun.

    Photoallergic and phototoxic reaction pictures

    Picture of a photoallergic reaction Picture of photoallergic and phototoxic dermatides Picture of a phototoxic drug reaction Picture of a phototoxic drug induced photosensitivity

    What are the symptoms of sun sensitivity (photosensitivity)?

    Symptoms of phototoxic reaction

    Individuals with phototoxic reactions may initially complain of a burning and stinging sensation. Then the redness typically occurs within 24 hours of the exposure to sun in the exposed areas of the body such as the forehead, nose, hands, arms, and lips. In severe cases, the sun protected areas of skin may be also be involved.

    The range of skin damage may vary from mild redness to swelling to blister formation (bullae) in more severe cases. The rash from this photosensitivity reaction usually resolves with sloughing off (desquamation) of the affected area within several days.

    Symptoms of photoallergic reactions

    Individuals with photoallergic reactions may initially complain of itching (pruritus). This is then followed by redness and possibly swelling and eruption of the involved area. Because this is considered an allergic reaction, there may be no symptoms for many days when the drug is taken for the first time. Subsequent exposure to the drug and the sun may cause a more rapid response in 1-2 days.

    Hyperpigmentation after reaction

    Hyperpigmentation (darkening) of the affected area of the skin may develop after the resolution of a phototoxicity reaction, but it is rare in a photoallergic reaction. In phototoxic reactions, high doses of the drug and long exposures to light may be required to cause the reaction.

    Phototoxic drugs

    Common phototoxic drugs include the following:

    Antibiotics
    • quinolones [for example, ciprofloxacin (Cipro, Cipro XR, Proquin XR), levofloxacin (Levaquin)]
    • tetracyclines [for example, tetracycline (Achromycin), doxycycline (Vibramycin, Oracea, Adoxa, Atridox and others)]
    • sulfonamides [for example, sulfamethoxazole and trimethoprim; cotrimoxazole (Bactrim, Septra), sulfamethoxazole (Gantanol)]

    Learn more about: Cipro | Cipro XR | Proquin XR | Levaquin | Vibramycin | Oracea | Adoxa | Atridox | Bactrim | Septra | Gantanol

    Antihistamines
    • diphenhydramine (Benadryl)

    Learn more about: Benadryl

    Malaria medications
    • quinine (Quinerva, Quinite, QM-260)
    • chloroquine (Aralen)
    • hydroxychloroquine (Plaquenil)

    Learn more about: Aralen | Plaquenil

    Cancer chemotherapy drugs
    • 5-fluorouracil (5-FU, Efudex, Carac, Fluoroplex)
    • vinblastine (Velban, Velsar)
    • dacarbazine (DTIC-Dome)

    Learn more about: Efudex | Carac | Fluoroplex | DTIC-Dome

    Cardiac drugs
    • amiodarone (Cordarone)
    • nifedipine (Procardia)
    • quinidine (Quinaglute, Quinidex)
    • diltiazem (Cardizem, Dilacor, Tiazac)

    Learn more about: Cordarone | Procardia | Quinidex | Cardizem | Tiazac

    Diuretics
    • furosemide (Lasix)
    • thiazides [hydrochlorothiazide (Hydrodiuril)

    Learn more about: Lasix

    Diabetic drugs
    • sulfonylureas [chlorpropamide (Diabinese), glyburide (Micronase, DiaBeta, Glynase)]

    Learn more about: Diabinese | Micronase | DiaBeta

    Painkillers
    • Nonsteroidal antiinflammatory drugs [naproxen (Naprosyn, Naprelan, Anaprox, Aleve), piroxicam (Feldene)

    Learn more about: Naprosyn | Naprelan | Feldene

    Skin medications
    • photodynamic therapy for skin cancer [ALA or 5-aminolevulinic acid (Levulan), Methyl-5-aminolevulinic acid)
    Acne medications
    • isotretinoin (Accutane)
    • acitretin (Soriatane)

    Learn more about: Accutane | Soriatane

    Psychiatric drugs
    • phenothiazines [chlorpromazine (Thorazine)]
    • tricyclic antidepressants [desipramine (Norpramin), imipramine (Tofranil)

    Learn more about: Accutane | Soriatane

    How is sun sensitivity (photosensitivity) diagnosed?

    The diagnosis is mainly made by a thorough history, examination, and review of the medications and duration of exposure to sun. It is important to ask when the medication was started and for how long the symptoms persisted.

    There are no diagnostic tests available, although a photo-patch test may be performed. This test is typically performed by a dermatologist (a doctor who specializes in diseases of the skin) by shining light onto different areas of the skin to see how long it will take for the light to cause redness. This test may be useful in evaluating photosensitivity to topical medications causing a photoallergic response. In cases of phototoxicity reactions, this test is generally not useful.

    What is the treatment for a photosensitizing drug reaction?

    Recognizing and discontinuing the photosensitizing drug is the most important step in treatment. In general, the usual sunburn prevention methods such as the use of sunscreens and avoidance of prolonged exposure to sun are important steps to take. Keeping the area of skin eruption moist and applying wet dressings may help relieve the symptoms. The reaction may last up to a few weeks.

    Topical steroid creams may be helpful in treating the redness, and antihistamines are generally helpful in minimizing the itching. In severe cases, a short course (10-14 days) of oral steroids, under the direction of a doctor, can be used.

    Is anyone taking these drugs at risk for developing sunburn?

    Not everyone taking any of these drugs will develop photosensitivity reactions. Certain individuals have more susceptibility to these medications than others.

    Can any foods or plants cause sun sensitivity (photosensitivity) reactions?

    Some vegetables and plants may cause sun sensitivity if they come into contact with the skin. Mango peel, lime juice, parsnips, or celery, for example, may cause temporary discoloration (darkening) of the skin contact area when in the sun. Common phototoxic fruits and vegetables include:

    • Lime
    • Celery
    • Carrots
    • Figs
    • Parsley
    • Parsnips

    Source: http://www.rxlist.com

    Recognizing and discontinuing the photosensitizing drug is the most important step in treatment. In general, the usual sunburn prevention methods such as the use of sunscreens and avoidance of prolonged exposure to sun are important steps to take. Keeping the area of skin eruption moist and applying wet dressings may help relieve the symptoms. The reaction may last up to a few weeks.

    Topical steroid creams may be helpful in treating the redness, and antihistamines are generally helpful in minimizing the itching. In severe cases, a short course (10-14 days) of oral steroids, under the direction of a doctor, can be used.

    Source: http://www.rxlist.com

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